Primo 100 Steroid Review: Is It Right for Your Muscle-Building Goals?
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Insulin-like Growth Factor 1 (IGF-1), also known as Somatomedin C, is a hormone alike in molecular structure to insulin, which plays an important role in childhood growth, and has anabolic effects in adults.
IGF-1 is one of many growth factors required for standard human development. IGF-1 is synthesized mostly by the liver but also centrally in numerous tissues.
IGF-1 consists of 70 amino acids. Similar to insulin, IGF-1 has an A and B chain connected by disulphide bonds. The C peptide region has 12 amino acids.
Usage
Insulin-like growth factor-1 (IGF-1) helps encourage normal bone and tissue growth and development and also has the ability to decrease blood glucose levels.
IGF-1 advances to fat cells and therefore burns fat. Subsequently, it increases lean body mass and decreases fat. These effects are desired mostly by athletes and bodybuilders. Increased IGF-1 levels are also comparable to weight gain. This weight gain is a result of lean body mass growth, not fat production.
IGF-1 is favored in the bodybuilding industry and for people who workout regularly. It helps enhance recovery time after workout and improves energy during the workout.
IGF-1 injections are common for adults and children if they have a growth hormone deficiency. IGF-1 contains many necessary amino acids that can help children who are not developing at a standard rate and supplement adults that are deficient.
Research has also shown that the anabolic effects of IGF-1 may reflect inhibited protein breakdown and stimulated protein synthesis in skeletal muscle and that this response may be caused by a direct effect of IGF-1 on muscle tissue, therefore assisting burns on the skin and other tissue abnormalities.
Mechanism of Action
IGF-1 is a hormone found naturally in human blood. Its primary function is to manage the effects of growth hormone in the body. Normal IGF-1 and growth hormone functions include tissue and bone growth. IGF-1 is formed in different tissues as a result of growth hormone in the blood.
IGF-1 promotes systemic body growth, and has growth-stimulating effects on mostly every cell in the body, mainly bone, cartilage, skeletal muscle, liver, kidney, nerve, skin and lung cells. As well as the insulin-like effects, IGF-1 can also manage cellular DNA synthesis.
Administration
Mode of Administration: Subcutaneous injection to a fleshy part of the body, typically to the stomach or abdominal area. IGF-1 can also be administered intramuscularly.
Before administering IGF-1, always be sure to use a clean and sterile syringe.
Hold the IGF-1 vial upright and insert the syringe in the center of the cap.
Draw the plunger until you have the correct amount (see ‘Dosage’ below) in the syringe and carefully remove it.
Before administering the syringe, use alcohol to cleanse the area of skin.
Pinch the skin around the area to be injected, leave about 2 cm on each side.
Hold the syringe at a 90 degree angle to your skin and swiftly insert the syringe.
Depress the plunger fully, until the syringe is empty, and carefully draw out.
Dosage
Dosage Amount: For lean muscle growth and fat loss
40 mcg - 50 mcg daily (men)
10 mcg - 20 mcg daily (women)
IGF-1 should not be injected more than twice daily
A typical dosage cycle of IGF-1 will continue for 2 to 12 weeks
Children and adults who are prescribed IGF-1 for development deficiency should consult with a care provider about correct dosing.
Side Effects
The side effects of IGF-1 can be similar to those of other growth hormones. These include growth of excess body tissue, also known as acromegaly, and damage to the joints, liver, and heart. IGF-1 could possibly cause joint pain, muscle pain, headaches and nausea. IGF-1 can also decrease levels of blood glucose, resulting in hypoglycemia. Researchers also associate IGF-1 with an increased risk of developing some cancers, such as lung, breast, colorectal and prostate.
Benefits
Facilitation of protein synthesis in the body
Regulation of stored fat and channeling it to be used for energy production, resulting in fat loss
Promotion of positive effects on metabolism and increasing lean body mass and muscle growth
Protection against autoimmune disease, heart disease and plaque buildup
Aid development in young children and adults deficient in essential amino acids
Improvement in blood sugar regulation
Promotion of optimal health, wellness and fitness in users
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**MOTs-C Peptides: A Detailed Description**
MOTs-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) peptides are a newly discovered class of small signaling molecules that have gained significant attention in the field of aging and longevity research. These peptides are derived from a specific region of the mitochondrial genome and have shown promising effects on various aspects of health and lifespan.
Mitochondria, often referred to as the "powerhouses" of cells, are responsible for generating energy in the form of adenosine triphosphate (ATP). As we age, mitochondrial function tends to decline, leading to a decrease in energy production and an increase in oxidative stress. This decline in mitochondrial function has been linked to various age-related diseases and the overall aging process.
MOTs-C peptides are believed to play a crucial role in maintaining mitochondrial health and function. Research has shown that these peptides can help improve mitochondrial respiration, enhance ATP production, and reduce oxidative stress. By doing so, MOTs-C peptides may have the potential to slow down the aging process and promote overall health and longevity.
Studies conducted on animal models and human cells have demonstrated several beneficial effects of MOTs-C peptides. One of the key findings is their ability to activate AMP-activated protein kinase (AMPK), a cellular energy sensor that regulates metabolism and promotes cellular homeostasis. Activation of AMPK has been associated with various health benefits, including improved insulin sensitivity, enhanced mitochondrial function, and increased lifespan.
Furthermore, MOTs-C peptides have shown anti-inflammatory properties by inhibiting the activation of nuclear factor kappa B (NF-κB), a key regulator of the inflammatory response. Chronic inflammation is a hallmark of aging and is closely linked to the development of age-related diseases such as cardiovascular disease, neurodegenerative disorders, and cancer. By reducing inflammation, MOTs-C peptides may help mitigate age-related inflammation and its associated health risks.
In addition to their effects on energy production and inflammation, MOTs-C peptides have been shown to enhance cellular stress resistance. They can activate cellular pathways involved in stress response, such as the NRF2 (nuclear factor erythroid 2-related factor 2) pathway, which plays a crucial role in antioxidant defense and detoxification. By activating these pathways, MOTs-C peptides may help protect cells from oxidative damage and enhance their ability to cope with stressors.
Although research on MOTs-C peptides is still in its early stages, the potential implications for human health and aging are exciting. Further studies are needed to fully understand the mechanisms of action, optimal dosage, and potential side effects of these peptides. However, the preliminary findings suggest that MOTs-C peptides hold promise as a potential therapeutic intervention for age-related diseases and the promotion of healthy aging.
It is important to note that MOTs-C peptides are currently being investigated in preclinical and early clinical trials, and they are not yet widely available as approved treatments. As with any emerging therapy, it is essential to exercise caution and consult with healthcare professionals before considering the use of MOTs-C peptides.
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